The Little Sisters of St. Francis of Assisi is an indigenous Congregation founded in 1932 by Irish missionary, Mother Mary Kevin. The Order was first started in Uganda, and has spread to Tanzania and Kenya, tending to the poor and the needy that they are called to love and serve, through apostolate ministry, such as education; healthcare, including managing hospitals and dispensaries; catechetical work; and social services, including caring for street children, single mothers, the aged, people with disabilities, and orphans.

In Kenya, LSOSF, now a population of over 700, is a blessing to the poor through the St. Francis Community Hospital, a Level 5 teaching and referral healthcare facility, located in Kasarani county.